Education
- PhD, 2002, MIT
- SB, 1996, Molecular Biology, University of Texas at Austin
Research Summary
We investigate how stem cells are regulated to regenerate missing tissues. We study the cellular events involved in this process and the attendant roles for regulatory genes that control regeneration steps. We utilize an array of methodologies, including high-throughput sequencing, RNA interference (RNAi) screening, and numerous assays and tools for phenotypic analysis to characterize regeneration regulatory genes.Awards
- Howard Hughes Medical Institute, HHMI Investigator, 2013
Key Publications
- Eye Absence Does Not Regulate Planarian Stem Cells during Eye Regeneration. LoCascio, SA, Lapan, SW, Reddien, PW. 2017. Dev Cell 40, 381-391.e3.
doi: 10.1016/j.devcel.2017.02.002PMID:28245923 - A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians. Wurtzel, O, Cote, LE, Poirier, A, Satija, R, Regev, A, Reddien, PW. 2015. Dev Cell 35, 632-645.
doi: 10.1016/j.devcel.2015.11.004PMID:26651295 - Muscle cells provide instructions for planarian regeneration. Witchley, JN, Mayer, M, Wagner, DE, Owen, JH, Reddien, PW. 2013. Cell Rep 4, 633-41.
doi: 10.1016/j.celrep.2013.07.022PMID:23954785 - Polarized notum activation at wounds inhibits Wnt function to promote planarian head regeneration. Petersen, CP, Reddien, PW. 2011. Science 332, 852-5.
doi: 10.1126/science.1202143PMID:21566195 - Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Wagner, DE, Wang, IE, Reddien, PW. 2011. Science 332, 811-6.
doi: 10.1126/science.1203983PMID:21566185
Recent Publications
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