{"id":10884,"date":"2019-04-03T08:53:51","date_gmt":"2019-04-03T12:53:51","guid":{"rendered":"https:\/\/biology.mit.edu\/?p=10884"},"modified":"2020-10-29T21:49:05","modified_gmt":"2020-10-30T01:49:05","slug":"pulin-li-joins-whitehead-institute","status":"publish","type":"post","link":"https:\/\/biology.mit.edu\/pulin-li-joins-whitehead-institute\/","title":{"rendered":"Pulin Li joins Whitehead Institute"},"content":{"rendered":"
Whitehead Institute announced today that the developmental and synthetic biologist Pulin Li will join the Institute in May as its newest Member. Li will also be appointed an assistant professor of biology at Massachusetts Institute of Technology (MIT). At Whitehead Institute, she will pursue studies that could, ultimately, lead to methods for programming cells to form replacement tissues and prosthetic cells for regenerative medicine.<\/p>\n
During her Ph.D. work at Harvard University, Li worked in the lab of Leonard Zon on hematopoietic stem cells using zebrafish as a model. Trained as a chemical biologist, she was interested in programming stem cells with chemicals to improve their engraftment efficiency upon transplantation. Working with zebrafish embryos, she discovered her passion for the fundamental molecular and cellular aspects of developmental biology. In particular, she wanted to understand how circuits of interacting genes, running as an automated program in individual cells, generate highly dynamic and yet choreographed multicellular behavior.<\/p>\n
For her postdoctoral research at California Institute of Technology with Michael B. Elowitz, Li chose to study morphogen-mediated tissue patterning, a key process in embryo development and tissue regeneration. To directly test the relationship between the architecture of the genetic circuits and precision of tissue patterning, she reconstituted morphogen gradients in a petri dish. This system allows researchers to systematically rewire genetic circuits, finely tune the key parameters, and quantitatively analyze the resulting spatiotemporal patterning dynamics. This cell-based multiscale reconstitution approach, from genetic circuits to single cells to multicellular behavior, provides an important new methodology for studying developmental and evolutionary questions. It could also offer a quantitative framework and molecular tools for tissue engineering.<\/p>\n
\u201cPulin\u2019s insightful work has demonstrated that she is just the kind of pathbreaking scientist we prize at Whitehead Institute: brilliant, creative, and passionately dedicated to fundamental biomedical discovery,\u201d says\u00a0David Page<\/a>, Whitehead Institute Director and Member. \u201cShe has taken a bottom\u2010up approach to understanding tissue patterning. As a result, for the first time, scientists are able to take a pathway apart, rebuild it, and analyze the role of each of its design features in a multicellular patterning process.\u201d<\/p>\n