{"id":11818,"date":"2019-06-24T10:58:37","date_gmt":"2019-06-24T14:58:37","guid":{"rendered":"https:\/\/biology.mit.edu\/?p=11818"},"modified":"2020-10-28T23:10:41","modified_gmt":"2020-10-29T03:10:41","slug":"joanne-stubbe-named-2020-priestley-medalist","status":"publish","type":"post","link":"https:\/\/biology.mit.edu\/joanne-stubbe-named-2020-priestley-medalist\/","title":{"rendered":"JoAnne Stubbe named 2020 Priestley Medalist"},"content":{"rendered":"

JoAnne Stubbe, the Novartis Professor of Chemistry and Biology, emerita, at the Massachusetts Institute of Technology, will receive the 2020 Priestley Medal, the American Chemical Society\u2019s highest honor.<\/p>\n

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\u201cJoAnne is the top mechanistic biochemist of her generation,\u201d says Stephen J. Lippard, one of Stubbe\u2019s colleagues in the MIT chemistry department. \u201cAmong her major achievements is understanding the controlled generation of radicals in biology.\u201d<\/p>\n<\/div>\n

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\u201cThroughout her career, JoAnne has taken on some of the experimentally most challenging problems, and time and time again, she provided insights that, while sometimes controversial when she first introduced them, have stood the test of time,\u201d says Wilfred van der Donk, a chemistry professor at the University of Illinois at Urbana-Champaign who was a postdoc in Stubbe\u2019s lab in the 1990s.<\/p>\n

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Stubbe is best known for figuring out the mechanism of ribonucleotide reductase, an enzyme that catalyzes the conversion of ribonucleotides used in RNA to deoxyribonucleotides used in DNA. That reaction is the only route in nature for making deoxyribonucleotides.<\/p>\n<\/div>\n

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Stubbe showed that the reduction at the 2\u2032 position on the ribose sugar ring involves hydrogen removal at the 3\u2032 position, which was unexpected because a 3\u2032 hydrogen still exists in the final structure. The reaction is particularly unusual because later crystal structures showed a metal cofactor initiates the electron transfer required to power the reduction from more than 35 \u00c5 from the reactive site. Such a long distance NetBet sportbetween the two sites was unexpected because it was too far for conventional electron transfer. Stubbe proposed and demonstrated that the transfer happens in multiple steps.<\/p>\n

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\u201cThe remarkable part of this now widely accepted mechanism is that no crystallographic information was available when JoAnne proposed it,\u201d van der Donk says. \u201cWhen the structure of the enzyme was reported years later, her predictions proved to be correct, and she herself later provided experimental evidence of many of the radical intermediates.\u201d Donald Hilvert, a chemistry professor at the Swiss Federal Institute of Technology Zurich, says, \u201cHer groundbreaking studies of ribonucleotide reductases revolutionized the field of enzymology.\u201d<\/p>\n<\/div>\n

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Stubbe also uncovered details of the mechanism of action of bleomycin, a cancer drug that works by cleaving double-stranded DNA. \u201cHer group determined the mechanism of this unusual process and solved the NMR structure of cobalt-substituted bleomycin bound to double-stranded DNA, a true tour de force,\u201d van der Donk says.<\/p>\n<\/div>\n

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Stubbe says she was shocked when she learned that she\u2019d been named the Priestley Medalist. She\u2019s been a member of ACS for more than 50 years, but as a biochemist she\u2019s considered herself to be an outsider. \u201cFor a long time, biochemists have not been thought highly of by chemists,\u201d she says. \u201cI\u2019m delighted that somebody chose me.\u201d ACS publishes C&EN.<\/p>\n<\/div>\n

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\u201cJoanne Stubbe is an excellent choice to receive the 2020 Priestley Medal. Her research into the mechanisms of key biochemical enzymes has significantly advanced the field. Her passion for the science has made her a role model for young women and men alike,\u201d 2019 ACS President Bonnie Charpentier says. \u201cAnd I\u2019m especially proud to welcome her into the prestigious ranks of the Priestley Medalists as only the fifth woman to receive this honor.\u201d<\/p>\n<\/div>\n

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Stubbe has received numerous awards for her research, including the\u00a02010 Welch Award<\/a>\u00a0and the\u00a02008 National Medal of Science<\/a>, which was awarded in 2009. She was elected to the National Academy of Sciences in 1992.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

JoAnne Stubbe, the Novartis Professor of Chemistry and Biology, emerita, at the Massachusetts Institute of Technology, will receive the 2020 Priestley Medal, the American Chemical Society\u2019s highest honor. \u201cJoAnne is the top mechanistic biochemist of her generation,\u201d says Stephen J. Lippard, one of Stubbe\u2019s colleagues in the MIT chemistry department. \u201cAmong her major achievements is […]<\/p>\n","protected":false},"author":16,"featured_media":6510,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","placement-placement-homepage"],"acf":[],"yoast_head":"\nJoAnne Stubbe named 2020 Priestley Medalist - MIT Department of Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biology.mit.edu\/joanne-stubbe-named-2020-priestley-medalist\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JoAnne Stubbe named 2020 Priestley Medalist\" \/>\n<meta property=\"og:description\" content=\"JoAnne Stubbe, the Novartis Professor of Chemistry and Biology, emerita, at the Massachusetts Institute of Technology, will receive the 2020 Priestley Medal, the American Chemical Society\u2019s highest honor. \u201cJoAnne is the top mechanistic biochemist of her generation,\u201d says Stephen J. 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