{"id":30083,"date":"2024-09-24T14:35:42","date_gmt":"2024-09-24T18:35:42","guid":{"rendered":"https:\/\/biology.mit.edu\/?p=30083"},"modified":"2024-09-27T09:00:33","modified_gmt":"2024-09-27T13:00:33","slug":"bsg-msrp-bio-student-profile-praise-lasekan-vos-lab","status":"publish","type":"post","link":"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/","title":{"rendered":"BSG-MSRP-Bio student profile: Praise Lasekan, Vos Lab"},"content":{"rendered":"
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A childhood interest in the complex worlds within an organism that the naked eye cannot see ultimately led Praise Lasekan to the BSG-MSRP-Bio program at MIT working in the Vos Lab in the Department of Biology at MIT.\u00a0<\/strong><\/p>\r\n\r\n\r\n


\r\n\r\n\r\n

Praise Lasekan talks about the fast protein liquid chromatography machines he used in the <\/span>Vos Lab<\/span><\/a> as though they were colleagues.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cWe have two of them,\u201d he explains. \u201cSam and Frodo.\u201d\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

FPLC machines separate and analyze proteins based on their properties, such as size, charge, and binding affinity. When Lasekan first saw the FPLC machines, the tubing and valves, hooked up to a computer, reminded him of a fancy piece of plumbing. Much like an expert plumber, proficiency\u200b\u200b with these machines required him to understand every valve and tube.<\/span><\/p>\r\n\r\n\r\n\r\n

Although Lasekan is a <\/span>Biology major with a Chemistry Minor <\/span>at the University of Maryland, Baltimore County, Lasekan had the opportunity to spend his summer living in Boston and working on MIT\u2019s campus as a <\/span>Bernard S. and Sophie G. Gould MIT Summer Research Program in Biology<\/span><\/a> student.<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cI loved every part of this summer: Waking up in the morning, coming to the lab, setting up some stuff \u2014 whether it goes well or not,\u201d Lasekan says. \u201cTaking that experience and coming back the next day, you’re ready to keep going and improving.\u201d<\/span><\/p>\r\n\r\n\r\n\r\n

Lasekan spent his days in the lab of <\/span>Seychelle Vos, Robert A. Swanson Career Development Professor of Life Sciences and HHMI Freeman Hrabowski Scholar<\/span><\/a>. The Vos Lab examines how genetic information is stored so compactly yet is still accessible enough for genes to be expressed. All cells in an organism have the same DNA, but the organization of that DNA and how genes are expressed determine why one cell becomes part of the liver and another cell part of the brain.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

Lasekan worked with a highly conserved protein that plays a role in gene transcription called CCCTCF-binding factor, or CTCF. He worked to understand how adding a phosphate group, a process called phosphorylation, affects CTCF\u2019s binding to DNA. Binding to DNA is the first step in the process of transcription, which creates proteins within a cell.<\/span><\/p>\r\n\r\n\r\n\r\n

The Vos lab uses various tools and techniques that Vos learned during her training, often using simple systems with limited components to study phenomena such as molecular structures, the dynamics of proteins and nucleic acids, and how structural alterations affect the function of these molecules. The lab has also recently been delving into more systemic work, such as removing genes from cells to observe how that affects gene expression.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cMy lab is a little unconventional in some ways,\u201d Vos says. \u201cWe use a lot of biochemistry and structural biology, but we want to use the tools of genetics and cell biology as well to understand how genome organization and genome expression are coupled.\u201d\u00a0<\/span><\/p>\r\n

\"\"
BSG-MSRP-Bio Student Praise with Graduate Student and mentor, Bonnie Su, of the Vos Lab.<\/figcaption><\/figure>\r\n\r\n\r\n\r\n

CTCF can play many roles during transcription, able to act as an activator or as a roadblock for transcription. Lasekan\u2019s mentor, <\/span>graduate student Bonnie Su<\/span><\/a>, has been trying to figure out how cells control CTCF behavior.<\/span><\/p>\r\n\r\n\r\n\r\n\r\n\r\n

\u201cWhat if the cell needed something done ASAP, and CTCF was blocking its route to its destination on a DNA sequence?\u201d Vos asks. \u201cHow does the cell regulate it?\u201d\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

Praise mutated different sites on CTCF that have been reported in previous research as possible points of phosphorylation of the CTCF protein. Several other amino acids can also be phosphorylated. Still, Su was particularly interested in the work other researchers have done on three specific sites along a segment called the zinc finger domain.\u00a0 A zinc finger domain is a zinc ion that helps proteins stabilize their shape and the domain has a function in various cellular processes such as genetic transcription. The ion is regulated by amino acids to give it a finger-like structure that helps in binding the protein to DNA during transcription.<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cBefore we went on a wild goose chase,\u201d Lasekan explains, \u201cwe needed to identify a specific area of the protein to concentrate on and examine the behavior of CTCF locally there.\u201d<\/span><\/p>\r\n\r\n\r\n\r\n

Off of the Drawing Board and Into the Laboratory<\/h2>\r\n\r\n\r\n\r\n

Lasekan was introduced to the microscopic world of the body \u2014 cells, organelles, molecules, and even atoms \u2014 in the pages of his secondary school science textbooks in Ondo, Nigeria. There began his curiosity about atomic structures, cells, and the complex worlds within an organism that the naked eye cannot see. He would spend much of his class time flipping through the pages of diagrams and ultimately decided to pursue science as his core focus during senior secondary school.<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cIt was there that I could take my first classes in chemistry, biology, and physics,\u201d he says. \u201cI realized I love all of the sciences, so my focus in school was science and technology.\u201d<\/span><\/p>\r\n\r\n\r\n\r\n

Initially drawn to engineering, Lasekan ended up dropping out of a technical drawing course.<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cI loved the course,\u201d Lasekan smiles, \u201cbut the course didn\u2019t like me one bit.\u201d\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

Lasekan\u2019s dreams shifted toward medicine and, with it, more science and math courses.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

When he graduated valedictorian from Staff Secondary School at the Federal University of Technology in Akure, his parents \u2014 both pharmacists \u2014 encouraged him to apply to university to become a medical doctor. However, getting into a good university is challenging in Nigeria.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

Praise opted instead to remain at home after graduating, building a successful business doing portrait photography. He also took chemistry, physics, and biology courses through <\/span>Cambridge University International<\/span><\/a>.<\/span><\/p>\r\n\r\n\r\n\r\n

Despite making good money with photography, Praise was determined to go to university but wasn\u2019t confident that he would get <\/span>in<\/span>. Nevertheless, an acquaintance encouraged him to apply to UMBC.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cIt was the only school I applied to, and I couldn\u2019t believe that I got in,\u201d says Lasekan.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

At UMBC, Lasekan discovered the pre-med track he\u2019d signed up for was not a good fit for him either \u2014 many of the fundamental questions he was curious about were beyond the scope of his courses. A friend who was working in a research lab on campus suggested that Lasekan should try to find a lab to work in, too.<\/span>\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cThey told me I might like what they’re doing there because of the level of questions that I ask,\u201d Lasekan says. \u201cSometimes people didn’t have answers for me, and maybe I could find some of those answers through research.\u201d\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

After he emailed PIs in biology and chemistry labs around campus, Lasekan was eventually accepted into the lab of <\/span>Dr. Erin Green, Associate Professor of Biological Sciences<\/span><\/a> at UMBC \u2014 his first experience doing research in the lab.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

Dr. Green focuses on trying to understand how post-translational modifications of proteins regulate functions, such as the establishment of proper states of gene expression and the ability of cells to respond to stress.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cDr. Green took a chance with me,\u201d Lasekan says. \u201cI am forever grateful to her for that.\u201d\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

MIT: A Destination for Scientific Discovery<\/span><\/h2>\r\n\r\n\r\n\r\n

When considering summer research programs, Praise applied to MIT, one institution he\u2019d always remembered from his childhood textbooks as the birthplace of many great inventions and scientific discoveries.<\/span> It\u2019s also one of the few programs in the U.S. that accepts international students.\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cI\u2019ve always had MIT at the back of my mind, but I didn\u2019t think they\u2019re looking for people like me,\u201d Lasekan says. When he saw the notification for his acceptance to the program pop up on his smartwatch, he screamed, startling some students walking by him in the hallway.<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cThis is one of the best institutions in the world, and I just got an opportunity to go there for ten weeks, actually do a project of my own under the mentorship of my PI,\u201d Lasekan recalls thinking. \u201cThis was a dream come true for me.\u201d<\/span><\/p>\r\n\r\n\r\n\r\n

In the Vos lab, Lasekan\u2019s interest in the fundamental questions of biology was not only acceptable but encouraged, especially by his mentor, Su.<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cBonnie always had the patience to sit down with me, explain concepts to me, and write out the math with me if I need her to,\u201d Lasekan says, \u201cand sometimes I need it 25 times, but she\u2019s there for me.\u201d\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

Now that the BSG-MSRP-Bio program has wrapped up, Praise has the confidence to set his sights higher than ever before \u2014 on the \u201cbig guys,\u201d the universities and institutions doing the sort of cutting-edge research that first caught his eye in the textbooks back home. Praise is eagerly preparing his graduate school applications for fall 2025, including MIT.<\/span><\/p>\r\n\r\n\r\n\r\n

\u201cAfter being here, surrounded by people from everywhere driven by the same purpose, I know there\u2019s an exciting future in science for me.\u201d\u00a0<\/span><\/p>\r\n\r\n\r\n\r\n

Want to know more about our BSG-MSRP-Bio Students? Read more testimonials and stories here.<\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"

A childhood interest in the complex worlds within an organism that the naked eye cannot see ultimately led Praise Lasekan to the BSG-MSRP-Bio program at MIT working in the Vos Lab in the Department of Biology at MIT.\u00a0 Praise Lasekan talks about the fast protein liquid chromatography machines he used in the Vos Lab as […]<\/p>\n","protected":false},"author":2316,"featured_media":30075,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6223,6227,6254],"tags":[],"class_list":["post-30083","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-building-68","category-diversity-outreach","category-special-program-students","placement-placement-homepage"],"acf":[],"yoast_head":"\nBSG-MSRP-Bio student profile: Praise Lasekan, Vos Lab - MIT Department of Biology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BSG-MSRP-Bio student profile: Praise Lasekan, Vos Lab\" \/>\n<meta property=\"og:description\" content=\"A childhood interest in the complex worlds within an organism that the naked eye cannot see ultimately led Praise Lasekan to the BSG-MSRP-Bio program at MIT working in the Vos Lab in the Department of Biology at MIT.\u00a0 Praise Lasekan talks about the fast protein liquid chromatography machines he used in the Vos Lab as […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"MIT Department of Biology\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-24T18:35:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-27T13:00:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/biology.mit.edu\/wp-content\/uploads\/2024\/09\/MSRP-Student-Praise-Lasekan-and-Seychelle-Vos-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1700\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Noah Daly\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Noah Daly\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/\",\"url\":\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/\",\"name\":\"BSG-MSRP-Bio student profile: Praise Lasekan, Vos Lab - MIT Department of Biology\",\"isPartOf\":{\"@id\":\"https:\/\/biology.mit.edu\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/biology.mit.edu\/wp-content\/uploads\/2024\/09\/MSRP-Student-Praise-Lasekan-and-Seychelle-Vos-scaled.jpg\",\"datePublished\":\"2024-09-24T18:35:42+00:00\",\"dateModified\":\"2024-09-27T13:00:33+00:00\",\"author\":{\"@id\":\"https:\/\/biology.mit.edu\/#\/schema\/person\/3245cc6b13e68fc9395445fc9b6b0a9b\"},\"breadcrumb\":{\"@id\":\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/biology.mit.edu\/bsg-msrp-bio-student-profile-praise-lasekan-vos-lab\/#primaryimage\",\"url\":\"https:\/\/biology.mit.edu\/wp-content\/uploads\/2024\/09\/MSRP-Student-Praise-Lasekan-and-Seychelle-Vos-scaled.jpg\",\"contentUrl\":\"https:\/\/biology.mit.edu\/wp-content\/uploads\/2024\/09\/MSRP-Student-Praise-Lasekan-and-Seychelle-Vos-scaled.jpg\",\"width\":2560,\"height\":1700,\"caption\":\"Praise Lasekan with Seychelle Vos, Robert A. 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