Education
- PhD, 1993, University of Vienna
- BS, 1989, Biology, University of Vienna
Research Summary
The overarching goal of my laboratory is to define the interplay of immunologic, virologic and host genetic factors that determine control of human viral infections, to guide vaccine development and immunotherapeutic interventions. To address this goal, we focus on HIV infection.Awards
- Bernard Fields Lectureship, 2015
- NIH Merit Award, 2011, 2004
- American Academy of Arts and Sciences, 2010
- National Academy of Medicine, 2009
- American Association of Physicians, 2000
- Doris Duke Charitable Foundation Distinguished Clinical Scientist Award, 1999
- American Society for Clinical Investigation, 1993
Key Publications
- Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Ndhlovu, ZM, Kazer, SW, Nkosi, T, Ogunshola, F, Muema, DM, Anmole, G, Swann, SA, Moodley, A, Dong, K, Reddy, T et al.. 2019. Sci Transl Med 11, .
doi: 10.1126/scitranslmed.aau0528PMID:31118290 - Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Gaiha, GD, Rossin, EJ, Urbach, J, Landeros, C, Collins, DR, Nwonu, C, Muzhingi, I, Anahtar, MN, Waring, OM, Piechocka-Trocha, A et al.. 2019. Science 364, 480-484.
doi: 10.1126/science.aav5095PMID:31048489 - Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Clayton, KL, Collins, DR, Lengieza, J, Ghebremichael, M, Dotiwala, F, Lieberman, J, Walker, BD. 2018. Nat Immunol 19, 475-486.
doi: 10.1038/s41590-018-0085-3PMID:29670239 - A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Park, RJ, Wang, T, Koundakjian, D, Hultquist, JF, Lamothe-Molina, P, Monel, B, Schumann, K, Yu, H, Krupzcak, KM, Garcia-Beltran, W et al.. 2017. Nat Genet 49, 193-203.
doi: 10.1038/ng.3741PMID:27992415 - Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion. Ranasinghe, S, Lamothe, PA, Soghoian, DZ, Kazer, SW, Cole, MB, Shalek, AK, Yosef, N, Jones, RB, Donaghey, F, Nwonu, C et al.. 2016. Immunity 45, 917-930.
doi: 10.1016/j.immuni.2016.09.015PMID:27760342 - Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Ndhlovu, ZM, Kamya, P, Mewalal, N, Kløverpris, HN, Nkosi, T, Pretorius, K, Laher, F, Ogunshola, F, Chopera, D, Shekhar, K et al.. 2015. Immunity 43, 591-604.
doi: 10.1016/j.immuni.2015.08.012PMID:26362266 - TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Chen, H, Ndhlovu, ZM, Liu, D, Porter, LC, Fang, JW, Darko, S, Brockman, MA, Miura, T, Brumme, ZL, Schneidewind, A et al.. 2012. Nat Immunol 13, 691-700.
doi: 10.1038/ni.2342PMID:22683743 - The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. International HIV Controllers Study, Pereyra, F, Jia, X, McLaren, PJ, Telenti, netbet sports betting appA, de Bakker, PI, Walker, BD, Ripke, S, Brumme, CJ, Pulit, SL et al.. 2010. Science 330, 1551-7.
doi: 10.1126/science.1195271PMID:21051598 - CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Kiepiela, P, Ngumbela, K, Thobakgale, C, Ramduth, D, Honeyborne, I, Moodley, E, Reddy, S, de Pierres, C, Mncube, Z, Mkhwanazi, N et al.. 2007. Nat Med 13, 46-53.
doi: 10.1038/nm1520PMID:17173051 - PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Day, CL, Kaufmann, DE, Kiepiela, P, Brown, JA, Moodley, ES, Reddy, S, Mackey, EW, Miller, JD, Leslie, AJ, DePierres, C et al.. 2006. Nature 443, 350-4.
doi: 10.1038/nature05115PMID:16921384
Recent Publications
- Expanded Antigen-Specific Elimination Assay to Measure Human CD8+ T Cell Cytolytic Potential. Collins, DR, Olatotse, MJ, Racenet, ZJ, Arshad, U, Çakan, E, Gaiha, GD, Clayton, KL, Walker, BD. 2024. Curr Protoc 4, e1109.
doi: 10.1002/cpz1.1109PMID:39023416 - Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection. Reddy, K, Lee, GQ, Reddy, N, Chikowore, TJB, Baisley, K, Dong, KL, Walker, BD, Yu, XG, Lichterfeld, M, Ndung'u, T et al.. 2024. medRxiv , .
doi: 10.1101/2024.02.16.24302713PMID:38947072 - Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy. Julg, B, Stephenson, KE, Tomaka, F, Walsh, SR, Sabrina Tan, C, Lavreys, L, Sarnecki, M, Ansel, JL, Kanjilal, DG, Jaegle, K et al.. 2024. NPJ Vaccines 9, 89.
doi: 10.1038/s41541-024-00876-2PMID:38782902 - Polymorphic residues in HLA-B that mediate HIV control distinctly NetBet sportmodulate peptide interactions with both TCR and KIR molecules. Tano-Menka, R, Singh, NK, Muzhingi, I, Li, X, Mandanas, MV, Kaseke, C, Crain, CR, Zhang, A, Ogunshola, FJ, Vecchiarello, L et al.. 2024. Structure 32, 1121-1136.e5.
doi: 10.1016/j.str.2024.04.015PMID:38733995 - Variable aging and storage of dissolved black carbon in the ocean. Coppola, AI, Druffel, ERM, Broek, TA, Haghipour, N, Eglinton, TI, McCarthy, M, Walker, BD. 2024. Proc Natl Acad Sci U S A 121, e2305030121.
doi: 10.1073/pnas.2305030121PMID:38517975 - Impact of HLA class I functional divergence on HIV control. Viard, M, O'hUigin, C, Yuki, Y, Bashirova, AA, Collins, DR, Urbach, JM, Wolinsky, S, Buchbinder, S, Kirk, GD, Goedert, JJ et al.. 2024. Science 383, 319-325.
doi: 10.1126/science.adk0777PMID:38236978 - T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19. Zonozi, R, Walters, LC, Shulkin, A, Naranbhai, V, Nithagon, P, Sauvage, G, Kaeske, C, Cosgrove, K, Nathan, A, Tano-Menka, R et al.. 2023. Sci Transl Med 15, eadh4529.
doi: 10.1126/scitranslmed.adh4529PMID:38019932 - The apparent quantum yield matrix (AQY-M) of CDOM photobleaching in estuarine, coastal, and oceanic surface waters. Zhu, X, Weiser, MW, Harringmeyer, JP, Kaiser, K, Walker, BD, Bélanger, S, Anderson, CH, Fichot, CG. 2024. Sci Total Environ 912, 168670.
doi: 10.1016/j.scitotenv.2023.168670PMID:37996032 - Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load. McLaren, PJ, Porreca, I, Iaconis, G, Mok, HP, Mukhopadhyay, S, Karakoc, E, Cristinelli, S, Pomilla, C, Bartha, I, Thorball, CW et al.. 2023. Nature 621, E42.
doi: 10.1038/s41586-023-06591-7PMID:37670157 - Africa-specific human genetic variation near CHD1L associates with HIV-1 load. McLaren, PJ, Porreca, I, Iaconis, G, Mok, HP, Mukhopadhyay, S, Karakoc, E, Cristinelli, S, Pomilla, C, Bartha, I, Thorball, CW et al.. 2023. Nature 620, 1025-1030.
doi: 10.1038/s41586-023-06370-4PMID:37532928
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