Education
- PhD, 1997, Stanford University
- BS, 1990, Biological Sciences, Stanford University
Research Summary
We aim to understand the code for RNA splicing: how the precise locations of introns and splice sites are identified in primary transcripts and how its specificity changes in different cell types. Toward this end, we are mapping the RNA-binding affinity spectra of dozens of human RNA-binding proteins and integrating this information with in vivo binding and activity data. We are also studying the functions of 3’ untranslated regions, including their roles in mRNA localization and microRNA regulation. The lab uses a combination of computational and experimental approaches to address these questions.Awards
- Schering-Plough Research Institute Award (ASBMB), 2007
- Overton Prize for Computational Biology (ISCB), 2001
Key Publications
- A large-scale binding and functional map of human RNA-binding proteins. Van Nostrand, EL, Freese, P, Pratt, GA, Wang, X, Wei, X, Xiao, R, Blue, SM, Chen, JY, Cody, NAL, Dominguez, D et al.. 2020. Nature 583, 711-719.
doi: 10.1038/s41586-020-2077-3PMID:32728246 - Exon-Mediated Activation of Transcription Starts. Fiszbein, A, Krick, KS, Begg, BE, Burge, CB. 2019. Cell 179, 1551-1565.e17.
doi: 10.1016/j.cell.2019.11.002PMID:31787377 - Sequence, Structure, and Context Preferences of Human RNA Binding Proteins. Dominguez, D, Freese, P, Alexis, MS, Su, A, Hochman, M, Palden, T, Bazile, C, Lambert, NJ, Van Nostrand, EL, Pratt, GA et al.. 2018. Mol Cell 70, 854-867.e9.
doi: 10.1016/j.molcel.2018.05.001PMID:29883606 - Distal Alternative Last Exons Localize mRNAs to Neural Projections. Taliaferro, JM, Vidaki, M, Oliveira, R, Olson, S, Zhan, L, Saxena, T, Wang, ET, Graveley, BR, Gertler, FB, Swanson, MS et al.. 2016. Mol Cell 61, 821-33.
doi: 10.1016/j.molcel.2016.01.020PMID:26907613 - Evolutionary netbet sports betting appdynamics of gene and isoform regulation in Mammalian tissues. Merkin, J, Russell, C, Chen, P, Burge, CB. 2012. Science 338, 1593-9.
doi: 10.1126/science.1228186PMID:23258891
Recent Publications
- Molecular and cellular context influences SCN8A variant function. Vanoye, CG, Abramova, TV, DeKeyser, JM, Ghabra, NF, Oudin, MJ, Burge, CB, Helbig, I, Thompson, CH, George, AL Jr. 2024. JCI Insight 9, .
doi: 10.1172/jci.insight.177530PMID:38771640 - An interpretable model of pre-mRNA splicing for animal and plant genes. McCue, K, Burge, CB. 2024. Sci Adv 10, eadn1547.
doi: 10.1126/sciadv.adn1547PMID:38718117 - Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro. Harris, SE, Alexis, MS, Giri, G, Cavazos, FF, Murn, J, Aleman, MM, Burge, CB, Dominguez, D. 2024. bioRxiv , .
doi: 10.1101/2024.01.29.577729PMID:38352439 - Regulatory features aid interpretation of 3'UTR variants. Romo, L, Findlay, SD, Burge, CB. 2024. Am J Hum Genet 111, 350-363.
doi: 10.1016/j.ajhg.2023.12.017PMID:38237594 - Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing. Gupta, K, Yang, C, McCue, K, Bastani, O, Sharp, PA, Burge, CB, Solar-Lezama, A. 2024. Genome Biol 25, 23.
doi: 10.1186/s13059-023-03162-xPMID:38229106 - Quantifying negative selection in human 3' UTRs uncovers constrained targets of RNA-binding proteins. Findlay, SD, Romo, L, Burge, CB. 2024. Nat Commun 15, 85.
doi: 10.1038/s41467-023-44456-9PMID:38168060 - Splicing quality control mediated by DHX15 and its G-patch activator SUGP1. Feng, Q, Krick, K, Chu, J, Burge, CB. 2023. Cell Rep 42, 113223.
doi: 10.1016/j.celrep.2023.113223PMID:37805921 - Systematic identification of disease-causing promoter and untranslated region variants in 8,040 undiagnosed individuals with rare disease. Martin-Geary, AC, Blakes, AJM, Dawes, R, Findlay, SD, Lord, J, Walker, S, Talbot-Martin, J, Wieder, N, D'Souza, EN, Fernandes, M et al.. 2023. medRxiv , .
doi: 10.1101/2023.09.12.23295416PMID:37745552 - Regulatory features aid interpretation of 3'UTR Variants. Romo, L, Findlay, SD, Burge, CB. 2023. bioRxiv , .
doi: 10.1101/2023.08.01.551549PMID:37577470 - Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes. ENCODE Project Consortium, Moore, JE, Purcaro, MJ, Pratt, HE, Epstein, CB, Shoresh, N, Adrian, J, Kawli, T, Davis, CA, Dobin, A et al.. 2022. Nature 605, E3.
doi: 10.1038/s41586-021-04226-3PMID:35474001
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