Education
- PhD, 1993, Harvard University
- BA, 1982, Biology, Goshen College
Research Summary
We study microRNAs and other small RNAs that specify the destruction and/or translational repression of mRNAs. We also study mRNAs, focusing on their untranslated regions and poly(A) tails, and how these regions recruit and mediate regulatory phenomena.Awards
- National Academy of Sciences, Member, 2011
- Howard Hughes Medical Institute, HHMI Investigator, 2005
- National Academy of Sciences Award in Molecular Biology, 2005
- AAAS Newcomb Cleveland Prize, 2002
Key Publications
- The molecular basis of coupling between poly(A)-tail length and translational efficiency. Xiang, K, Bartel, DP. 2021. Elife 10, .
doi: 10.7554/eLife.66493PMID:34213414 - The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi, CY, Kingston, ER, Kleaveland, B, Lin, DH, Stubna, MW, Bartel, DP. 2020. Science 370, .
doi: 10.1126/science.abc9359PMID:33184237 - The biochemical basis of microRNA targeting efficacy. McGeary, SE, Lin, KS, Shi, CY, Pham, TM, Bisaria, N, Kelley, GM, Bartel, DP. 2019. Science 366, .
doi: 10.1126/science.aav1741PMID:31806698 - Excised linear introns regulate growth in yeast. Morgan, JT, Fink, GR, Bartel, DP. 2019. Nature 565, 606-611.
doi: 10.1038/s41586-018-0828-1PMID:30651636 - A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Kleaveland, B, Shi, CY, Stefano, J, Bartel, DP. 2018. Cell 174, 350-362.e17.
doi: 10.1016/j.cell.2018.05.022PMID:29887379
Recent Publications
- The structural basis for RNA slicing by human Argonaute2. Mohamed, AA, Wang, PY, Bartel, DP, Vos, SM. 2024. bioRxiv , .
doi: 10.1101/2024.08.19.608718PMID:39229170 - The guide-RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex. Wang, PY, Bartel, DP. 2024. Mol Cell 84, 2918-2934.e11.
doi: 10.1016/j.molcel.2024.06.026PMID:39025072 - The guide RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex. Wang, PY, Bartel, DP. 2024. bioRxiv , .
doi: 10.1101/2023.10.15.562437PMID:38766062 - Nuclear release of eIF1 globally increases stringency of start-codon selection to preserve mitotic arrest physiology. Ly, J, Xiang, K, Su, KC, Sissoko, GB, Bartel, DP, Cheeseman, IM. 2024. bioRxiv , .
doi: 10.1101/2024.04.06.588385PMID:38617206 - Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos. Xiang, K, Ly, J, Bartel, DP. 2024. Dev Cell 59, 1058-1074.e11.
doi: 10.1016/j.devcel.2024.02.007PMID:38460509 - ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development. Shi, CY, Elcavage, LE, Chivukula, RR, Stefano, J, Kleaveland, B, Bartel, DP. 2023. Genome Res 33, 1482-1496.
doi: 10.1101/gr.278073.123PMID:37532519 - A statistical approach for identifying primary substrates of ZSWIM8-mediated microRNA degradation in small-RNA sequencing data. Wang, NetBet live casinoPY, Bartel, DP. 2023. BMC Bioinformatics 24, 195.
doi: 10.1186/s12859-023-05306-zPMID:37170259 - Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development. Kingston, ER, Blodgett, LW, Bartel, DP. 2022. Mol Cell 82, 3872-3884.e9.
doi: 10.1016/j.molcel.2022.08.029PMID:36150386 - The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Hallacli, E, Kayatekin, C, Nazeen, S, Wang, XH, Sheinkopf, Z, Sathyakumar, S, Sarkar, S, Jiang, X, Dong, X, Di Maio, R et al.. 2022. Cell 185, 2035-2056.e33.
doi: 10.1016/j.cell.2022.05.008PMID:35688132 - The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation. Eisen, TJ, Li, JJ, Bartel, DP. 2022. RNA 28, 808-831.
doi: 10.1261/rna.079046.121PMID:35273099
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