Education
- PhD, 1990, Stanford University
- BS, 1982, Biology, Wuhan University
Research Summary
We seek to understand the immune system and its application in cancer immunotherapy and vaccine development. We study the molecular and cellular mechanisms behind immunological and disease processes, leveraging the vast array of genomic data, humanized mice and clinical samples.Awards
- American Association for the Advancement of Science, Fellow, 2012
Key Publications
- High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming. Hu, G, Su, Y, Kang, BH, Fan, netbet sports betting appZ, Dong, T, Brown, DR, Cheah, J, Wittrup, KD, Chen, J. 2021. Nat Commun 12, 773.
doi: 10.1038/s41467-021-21066-xPMID:33536439 - CAR-T cells targeting a nucleophosmin neoepitope exhibit potent specific activity in mouse models of acute myeloid leukaemia. Xie, G, Ivica, NA, Jia, B, Li, Y, Dong, H, Liang, Y, Brown, D, Romee, R, Chen, J. 2021. Nat Biomed Eng 5, 399-413.
doi: 10.1038/s41551-020-00625-5PMID:33046866 - MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li, Y, Ivica, NA, Dong, T, Papageorgiou, DP, He, Y, Brown, DR, Kleyman, M, Hu, G, Chen, WW, Sullivan, LB et al.. 2020. Nat Commun 11, 4837.
doi: 10.1038/s41467-020-18607-1PMID:32973183 - Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. Hu, G, Dong, T, Wang, S, Jing, H, Chen, J. 2019. EBioMedicine 45, 563-577.
doi: 10.1016/j.ebiom.2019.06.039PMID:31278070 - Sensitizing protective tumor microenvironments to antibody-mediated therapy. Pallasch, CP, Leskov, I, Braun, CJ, Vorholt, D, Drake, A, Soto-Feliciano, YM, Bent, EH, Schwamb, J, Iliopoulou, B, Kutsch, N et al.. 2014. Cell 156, 590-602.
doi: 10.1016/j.cell.2013.12.041PMID:24485462
Recent Publications
- CAR memory-like NK cells targeting the membrane proximal domain of mesothelin demonstrate promising activity in ovarian cancer. Tarannum, M, Dinh, K, Vergara, J, Birch, G, Abdulhamid, NetBet sportYZ, Kaplan, IE, Ay, O, Maia, A, Beaver, O, Sheffer, M et al.. 2024. Sci Adv 10, eadn0881.
doi: 10.1126/sciadv.adn0881PMID:38996027 - Adhesive anti-fibrotic interfaces on diverse organs. Wu, J, Deng, J, Theocharidis, G, Sarrafian, TL, Griffiths, LG, Bronson, RT, Veves, A, Chen, J, Yuk, H, Zhao, X et al.. 2024. Nature 630, 360-367.
doi: 10.1038/s41586-024-07426-9PMID:38778109 - Bosutinib Stimulates Macrophage Survival, Phagocytosis, and Intracellular Killing of Bacteria. da Silva, RAG, Stocks, CJ, Hu, G, Kline, KA, Chen, J. 2024. ACS Infect Dis 10, 1725-1738.
doi: 10.1021/acsinfecdis.4c00086PMID:38602352 - Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapy. Yang, S, Sheffer, M, Kaplan, IE, Wang, Z, Tarannum, M, Dinh, K, Abdulhamid, Y, Shapiro, R, Porter, R, Soiffer, R et al.. 2024. Res Sq , .
doi: 10.21203/rs.3.rs-4031911/v1PMID:38562821 - Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis. Dong, T, Hu, G, Fan, Z, Wang, H, Gao, Y, Wang, S, Xu, H, Yaffe, MB, Vander Heiden, MG, Lv, G et al.. 2024. Nat Commun 15, 807.
doi: 10.1038/s41467-024-45167-5PMID:38280848 - Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants. Ye, Z, Bonam, SR, McKay, LGA, Plante, JA, Walker, J, Zhao, Y, Huang, C, Chen, J, Xu, C, Li, Y et al.. 2023. Proc Natl Acad Sci U S A 120, e2311752120.
doi: 10.1073/pnas.2311752120PMID:38134199 - IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy. Pan, L, Cho, KS, Wei, X, Xu, F, Lennikov, A, Hu, G, Tang, J, Guo, S, Chen, J, Kriukov, E et al.. 2023. Cell Rep 42, 112889.
doi: 10.1016/j.celrep.2023.112889PMID:37527036 - Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis. da Silva, RAG, Wong, JJ, Antypas, H, Choo, PY, Goh, K, Jolly, S, Liang, C, Tay Kwan Sing, L, Veleba, M, Hu, G et al.. 2023. Sci Adv 9, eadd9280.
doi: 10.1126/sciadv.add9280PMID:36812322 - Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo. Chew, M, Ye, W, Omelianczyk, RI, Pasaje, CF, Hoo, R, Chen, Q, Niles, JC, Chen, J, Preiser, P. 2022. Nat Commun 13, 4067.
doi: 10.1038/s41467-022-31741-2PMID:35831417 - Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia. Dong, H, Ham, JD, Hu, G, Xie, G, Vergara, J, Liang, Y, Ali, A, Tarannum, M, Donner, H, Baginska, J et al.. 2022. Proc Natl Acad Sci U S A 119, e2122379119.
doi: 10.1073/pnas.2122379119PMID:35696582