Education
- PhD, 2000, University of Chicago; MD, 2002, University of Chicago
- SB, 1994, Biological Chemistry, University of Chicago
Research Summary
We study the biochemical pathways cells use and how they are regulated to meet the metabolic requirements of cells in different physiological situations. We focus on the role of metabolism in cancer, particularly how metabolic pathways support cell proliferation. We aim to translate our understanding of cancer cell metabolism into novel cancer therapies.Awards
- Howard Hughes Medical Institute Faculty Scholar, 2016
- SU2C Innovative Research Grant Recipient, 2016
Recent Publications
- Cancer tissue of origin constrains the growth and metabolism of metastases. Sivanand, S, Gultekin, Y, Winter, PS, Vermeulen, SY, Tchourine, KM, Abbott, KL, Danai, LV, Gourgue, F, Do, BT, Crowder, K et al.. 2024. Nat Metab , .
doi: 10.1038/s42255-024-01105-9PMID:39160333 - Macrophages dig into the obesity paradox in cancer. Nabel, CS, Gourgue, F, Vander Heiden, MG. 2024. Immunity 57, 1731-1733.
doi: 10.1016/j.immuni.2024.07.013PMID:39142274 - Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress. Do, BT, Hsu, PP, Vermeulen, SY, Wang, Z, Hirz, T, Abbott, KL, Aziz, N, Replogle, JM, Bjelosevic, S, Paolino, J et al.. 2024. Dev Cell 59, 2203-2221.e15.
doi: 10.1016/j.devcel.2024.05.010PMID:38823395 - Metabolite netbet sports betting appprofiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability. Abbott, KL, Ali, A, Reinfeld, BI, Deik, A, Subudhi, S, Landis, MD, Hongo, RA, Young, KL, Kunchok, T, Nabel, CS et al.. 2024. Elife 13, .
doi: 10.7554/eLife.95652PMID:38787918 - Effects of aging on glucose and lipid metabolism in mice. Lien, EC, Vu, N, Westermark, AM, Danai, LV, Lau, AN, Gültekin, Y, Kukurugya, MA, Bennett, BD, Vander Heiden, MG. 2023. bioRxiv , .
doi: 10.1101/2023.12.17.572088PMID:38187759 - Metabolite netbet sports betting appprofiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability. Abbott, KL, Ali, A, Reinfeld, BI, Deik, A, Subudhi, S, Landis, MD, Hongo, RA, Young, KL, Kunchok, T, Nabel, CS et al.. 2024. bioRxiv , .
doi: 10.1101/2023.12.24.573250PMID:38187626 - Screening in serum-derived medium reveals differential response to compounds targeting metabolism. Abbott, KL, Ali, A, Casalena, D, Do, BT, Ferreira, R, Cheah, JH, Soule, CK, Deik, A, Kunchok, T, Schmidt, DR et al.. 2023. Cell Chem Biol 30, 1156-1168.e7.
doi: 10.1016/j.chembiol.2023.08.007PMID:37689063 - Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer. Schmidt, DR, Gramatikov, IMT, Sheen, A, Williams, CL, Hurwitz, M, Dodge, LE, Holupka, E, Kiger, WS 3rd, Cornwall-Brady, MR, Huang, W et al.. 2023. Commun Med (Lond) 3, 108.
doi: 10.1038/s43856-023-00336-3PMID:37558833 - The bidirectional relationship between metabolism and cell cycle control. Diehl, FF, Sapp, KM, Vander Heiden, MG. 2024. Trends Cell Biol 34, 136-149.
doi: 10.1016/j.tcb.2023.05.012PMID:37385879 - GOT2 consider the tumor microenvironment. Do, BT, Vander Heiden, MG. 2022. Trends Cancer 8, 884-886.
doi: 10.1016/j.trecan.2022.09.004PMID:36153305
Multimedia