Education
- PhD, 1979, Yale University
- BS, 1975, Biological Sciences, Indiana University
Research Summary
We use experimental and computational technologies to determine how signaling pathways, transcription factors, chromatin regulators and small RNAs regulate gene expression in healthy and diseased cells. Our interests range from the basic molecular mechanisms behind gene control to drug development for cancer and other diseases caused by gene misregulation.Awards
- National Academy of Medicine, Member, 2019
- National Academy of Sciences, Member, 2012
Key Publications
- Biomolecular netbet sports bettingCondensates and Cancer. Boija, A, Klein, IA, Young, RA. 2021. Cancer Cell 39, 174-192.
doi: 10.1016/j.ccell.2020.12.003PMID:33417833 - RNA-Mediated Feedback Control of Transcriptional Condensates. Henninger, JE, Oksuz, O, Shrinivas, K, Sagi, I, LeRoy, G, Zheng, MM, Andrews, JO, Zamudio, AV, Lazaris, C, Hannett, NM et al.. 2021. Cell 184, 207-225.e24.
doi: 10.1016/j.cell.2020.11.030PMID:33333019 - Partitioning of cancer therapeutics in nuclear condensates. Klein, IA, Boija, A, Afeyan, LK, Hawken, SW, Fan, M, Dall'Agnese, A, Oksuz, O, Henninger, JE, Shrinivas, K, Sabari, BR et al.. 2020. Science 368, 1386-1392.
doi: 10.1126/science.aaz4427PMID:32554597 - Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Boija, A, Klein, IA, Sabari, BR, Dall'Agnese, A, Coffey, EL, Zamudio, AV, Li, CH, Shrinivas, K, Manteiga, JC, Hannett, NM et al.. 2018. Cell 175, 1842-1855.e16.
doi: 10.1016/j.cell.2018.10.042PMID:30449618 - Coactivator condensation at super-enhancers links phase separation and gene control. Sabari, BR, Dall'Agnese, A, Boija, A, Klein, IA, Coffey, EL, Shrinivas, K, Abraham, BJ, Hannett, NM, Zamudio, AV, Manteiga, JC et al.. 2018. Science 361, .
doi: 10.1126/science.aar3958PMID:29930091
Recent Publications
- Protein codes promote selective subcellular compartmentalization. NetBet sportKilgore, HR, Chinn, I, Mikhael, PG, Mitnikov, I, Van Dongen, C, Zylberberg, G, Afeyan, L, Banani, S, Wilson-Hawken, S, Lee, TI et al.. 2024. bioRxiv , .
doi: 10.1101/2024.04.15.589616PMID:38659952 - Author Correction: Distinct chemical environments in biomolecular condensates. Kilgore, HR, Mikhael, PG, Overholt, KJ, Boija, A, Hannett, NM, Van Dongen, C, Lee, TI, Chang, YT, Barzilay, R, Young, RA et al.. 2023. Nat Chem Biol 19, 1561.
doi: 10.1038/s41589-023-01491-3PMID:37880420 - Distinct chemical environments in biomolecular condensates. Kilgore, HR, Mikhael, PG, Overholt, KJ, Boija, A, Hannett, NM, Van Dongen, C, Lee, TI, Chang, YT, Barzilay, R, Young, RA et al.. 2024. Nat Chem Biol 20, 291-301.
doi: 10.1038/s41589-023-01432-0PMID:37770698 - Transcription factors interact with RNA to regulate genes. Oksuz, O, Henninger, JE, Warneford-Thomson, R, Zheng, MM, Erb, H, Vancura, A, Overholt, KJ, Hawken, SW, Banani, SF, Lauman, R et al.. 2023. Mol Cell 83, 2449-2463.e13.
doi: 10.1016/j.molcel.2023.06.012PMID:37402367 - The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance. Dall'Agnese, A, Platt, JM, Zheng, MM, Friesen, M, Dall'Agnese, G, Blaise, AM, Spinelli, JB, Henninger, JE, Tevonian, EN, Hannett, NM et al.. 2022. Nat Commun 13, 7522.
doi: 10.1038/s41467-022-35176-7PMID:36473871 - Genetic variation associated with condensate dysregulation in disease. Banani, SF, Afeyan, LK, Hawken, SW, Henninger, JE, Dall'Agnese, A, Clark, VE, Platt, JM, Oksuz, NetBet live casinoO, Hannett, NM, Sagi, I et al.. 2022. Dev Cell 57, 1776-1788.e8.
doi: 10.1016/j.devcel.2022.06.010PMID:35809564 - Learning the chemical grammar of biomolecular condensates. Kilgore, HR, Young, RA. 2022. Nat Chem Biol 18, 1298-1306.
doi: 10.1038/s41589-022-01046-yPMID:35761089 - RNA in formation and regulation of transcriptional condensates. Sharp, PA, Chakraborty, AK, Henninger, JE, Young, RA. 2022. RNA 28, 52-57.
doi: 10.1261/rna.078997.121PMID:34772787 - Biomolecular netbet sports bettingCondensates and Cancer. Boija, A, Klein, IA, Young, RA. 2021. Cancer Cell 39, 174-192.
doi: 10.1016/j.ccell.2020.12.003PMID:33417833 - RNA-Mediated Feedback Control of Transcriptional Condensates. Henninger, JE, Oksuz, O, Shrinivas, K, Sagi, I, LeRoy, G, Zheng, MM, Andrews, JO, Zamudio, AV, Lazaris, C, Hannett, NM et al.. 2021. Cell 184, 207-225.e24.
doi: 10.1016/j.cell.2020.11.030PMID:33333019
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